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Advancing Computational Biology and Bioinformatics Research Through Open Innovation Competitions

By: Andrea Blasco, Michael G. Endres, Rinat A. Sergeev, Anup Jonchhe, Max Macaluso, Rajiv Narayan, Ted Natoli, Jin H. Paik, Bryan Briney, Chunlei Wu, Andrew I. Su, Aravind Subramanian and Karim R. Lakhani
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Abstract

Open data science and algorithm development competitions offer a unique avenue for rapid discovery of better computational strategies. We highlight three examples in computational biology and bioinformatics research where the use of competitions has yielded significant performance gains over established algorithms. These include studying algorithms for antibody clustering, imputing gene expression data, and querying the Connectivity Map (CMap). Performance gains are evaluated quantitatively using realistic, albeit sanitized, data sets. The solutions produced through these competitions are then examined with respect to their utility and the prospects for implementation in the field. We present the decision process and competition design considerations that lead to these successful outcomes as a model for researchers who want to use competitions and non-domain crowds as collaborators to further their research.

Keywords

Computational Biology; Bioinformatics; Innovation Competitions; Research; Collaborative Innovation and Invention

Citation

Blasco, Andrea, Michael G. Endres, Rinat A. Sergeev, Anup Jonchhe, Max Macaluso, Rajiv Narayan, Ted Natoli, Jin H. Paik, Bryan Briney, Chunlei Wu, Andrew I. Su, Aravind Subramanian, and Karim R. Lakhani. "Advancing Computational Biology and Bioinformatics Research Through Open Innovation Competitions." PLoS ONE 14, no. 9 (September 2019).
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About The Author

Karim R. Lakhani

Technology and Operations Management
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  • Navigating the Jagged Technological Frontier: Field Experimental Evidence of the Effects of AI on Knowledge Worker Productivity and Quality By: Fabrizio Dell'Acqua, Edward McFowland III, Ethan Mollick, Hila Lifshitz-Assaf, Katherine C. Kellogg, Saran Rajendran, Lisa Krayer, François Candelon and Karim R. Lakhani
  • Consuming Contests: The Effect of Outcome Uncertainty on Spectator Attendance in the Australian Football League By: Patrick Ferguson and Karim R. Lakhani
  • The Crowdless Future? How Generative AI Is Shaping the Future of Human Crowdsourcing By: Léonard Boussioux, Jacqueline N. Lane, Miaomiao Zhang, Vladimir Jacimovic and Karim R. Lakhani
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