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Diseases →
- 2016
- Teaching Note
Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired
By: Rosabeth M. Kanter, Tessa Natanay Hamilton and Ai-Ling Jamila Malone
Teaching note for case 314029. Following a successful military career as an Army Nurse, achieving rank as Major General, becoming the first female Acting Surgeon General of the Army, and the 22nd Chief of the Army Nurse Corps, Pollock developed a vested interest in...
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Keywords:
Health Care;
Health Care Education;
Insurance Companies;
Military;
Leadership Skills;
Health Care and Treatment;
Education;
Insurance;
Business Startups;
Information Technology;
Applications and Software;
Change Management;
Health Industry;
Information Technology Industry
Kanter, Rosabeth M., Tessa Natanay Hamilton, and Ai-Ling Jamila Malone. "Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired." Harvard Business Publishing Teaching Note 316-036, 2016. (Harvard Advanced Leadership Initiative.)
- 2016
- Article
Penalized Fast Subset Scanning
By: Skyler Speakman, Sriram Somanchi, Edward McFowland III and Daniel B. Neill
We present the penalized fast subset scan (PFSS), a new and general framework for scalable and accurate pattern detection. PFSS enables exact and efficient identification of the most anomalous subsets of the data, as measured by a likelihood ratio scan statistic....
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Keywords:
Disease Surveillance;
Likelihood Ratio Statistic;
Pattern Detection;
Scan Statistic;
Mathematical Methods
Speakman, Skyler, Sriram Somanchi, Edward McFowland III, and Daniel B. Neill. "Penalized Fast Subset Scanning." Journal of Computational and Graphical Statistics 25, no. 2 (2016): 382–404. (Selected for “Best of JCGS” invited session by the journal’s editor in chief.)
- September 2015
- Article
Design and Implementation of a Privacy Preserving Electronic Health Record Linkage Tool in Chicago
By: Abel Kho, John Cashy, Kathryn Jackson, Adam Pah, Satyender Goel, Jorn Boehnke, John Eric Humphries, Scott Duke Kominers and et al.
Objective
To design and implement a tool that creates a secure, privacy preserving linkage of electronic health record (EHR) data across multiple sites in a large metropolitan area in the United States (Chicago, IL), for use in clinical... View Details
To design and implement a tool that creates a secure, privacy preserving linkage of electronic health record (EHR) data across multiple sites in a large metropolitan area in the United States (Chicago, IL), for use in clinical... View Details
Keywords:
Information;
Customers;
Safety;
Rights;
Ethics;
Entrepreneurship;
Health Care and Treatment;
Health Industry;
Chicago
Kho, Abel, John Cashy, Kathryn Jackson, Adam Pah, Satyender Goel, Jorn Boehnke, John Eric Humphries, Scott Duke Kominers, and et al. "Design and Implementation of a Privacy Preserving Electronic Health Record Linkage Tool in Chicago." Journal of the American Medical Informatics Association 22, no. 5 (September 2015): 1072–1080.
- July 2015
- Background Note
The State of U.S. Public Health: Challenges and Trends
By: Rosabeth M. Kanter, Howard Koh and Pamela Yatsko
The World Health Organization defines health as "a state of complete physical, mental, and social well-being and not merely the absence of disease and infirmity." For many Americans, the World Health Organization's definition of true health seems unattainable, given...
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Kanter, Rosabeth M., Howard Koh, and Pamela Yatsko. "The State of U.S. Public Health: Challenges and Trends." Harvard Business School Background Note 316-001, July 2015.
- 2015
- Article
Scalable Detection of Anomalous Patterns With Connectivity Constraints
By: Skyler Speakman, Edward McFowland III and Daniel B. Neill
We present GraphScan, a novel method for detecting arbitrarily shaped connected clusters in graph or network data. Given a graph structure, data observed at each node, and a score function defining the anomalousness of a set of nodes, GraphScan can efficiently and...
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Speakman, Skyler, Edward McFowland III, and Daniel B. Neill. "Scalable Detection of Anomalous Patterns With Connectivity Constraints." Journal of Computational and Graphical Statistics 24, no. 4 (2015): 1014–1033.
- March 2015 (Revised January 2024)
- Case
CV Ingenuity (A): How to Evaluate the Commercial Viability of New Health Care Technologies
By: Regina E. Herzlinger and Andrew Otazo
Duke Rohlen (HBS MBA ’01) hoped to win over a prominent venture capital investor for Series B financing of his firm CVI that was creating a drug-eluting balloon (DES) to treat peripheral arterial disease. As a second-mover, Duke felt he was more likely to acquire...
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Keywords:
CV Ingenuity;
CVI;
Drug Eluting Balloon;
DEB;
Drug Eluting Stent;
Angioplasty Balloon;
FoxHollow;
Medical Device;
Medical Device Startup;
Premarket Approval;
PMA;
Lutonix;
Stellarex;
LEVANT;
ILLUMENATE;
Clinical Trials;
Peripheral Arterial Disease;
PAD;
Healthcare Startups;
Covidien;
Health Care and Treatment;
Health Testing and Trials;
Business Startups;
Commercialization;
Health Industry;
Medical Devices and Supplies Industry;
United States;
Europe
Herzlinger, Regina E., and Andrew Otazo. "CV Ingenuity (A): How to Evaluate the Commercial Viability of New Health Care Technologies." Harvard Business School Case 315-045, March 2015. (Revised January 2024.)
- March 2015 (Revised February 2022)
- Supplement
CV Ingenuity (B): Epilogue
By: Regina E. Herzlinger and Andrew Otazo
Duke Rohlen used a lea-nfunding, iconoclastic strategy for his start up for a drug eluding balloon for peripheral artery disease. His giant competitors were first movers. Did Duke obtain the funding he sought? How did his DEB fare versus that of his competitors?
The...
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Keywords:
CV Ingenuity;
CVI;
Drug Eluting Balloon;
DEB;
Drug Eluting Stent;
Angioplasty Balloon;
FoxHollow;
Medical Device;
Medical Device Startup;
Premarket Approval;
PMA;
Lutonix;
Stellarex;
LEVANT;
ILLUMENATE;
Clinical Trials;
Peripheral Arterial Disease;
PAD;
Healthcare Startups;
Covidien;
Health Care and Treatment;
Health Testing and Trials;
Business Startups;
Commercialization;
Strategy;
Health Industry;
Medical Devices and Supplies Industry;
United States;
Europe
Herzlinger, Regina E., and Andrew Otazo. "CV Ingenuity (B): Epilogue." Harvard Business School Supplement 315-087, March 2015. (Revised February 2022.)
- March 2015
- Case
Twine Health
By: Robert S. Huckman, Ariel D. Stern and Matthew G. Preble
In late 2014, Dr. John Moore (CEO), Frank Moss (chairman), and Scott Gilroy (CTO) of Twine Health (Twine) had to resolve several challenges that threatened to restrict the widespread dissemination of its sole product, Twine. Twine was a cloud-based platform that...
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Keywords:
Health Care;
Chronic Disease;
Technology Adoption;
Digital Health;
Health Acceleration Challenge;
Strategy;
Disease Management;
Health;
Health Care and Treatment;
Information Technology;
Mobile and Wireless Technology;
Health Industry;
United States;
Massachusetts
Huckman, Robert S., Ariel D. Stern, and Matthew G. Preble. "Twine Health." Harvard Business School Case 615-068, March 2015.
- February 2015 (Revised June 2017)
- Case
Intrapreneurship at DaVita HealthCare Partners
By: Joseph B. Fuller, David J. Collis and Matthew G. Preble
Josh Golomb, president and general manager of DaVita Rx (Rx), was about to meet with Kent Thiry, CEO of Rx's corporate parent, DaVita Healthcare Partners Inc. (DaVita), in August 2013. The two would discuss whether Golomb should lead a new DaVita venture, Paladina...
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Keywords:
Intrapreneurship;
Entrepreneurial Organizations;
Startup Management;
Startup;
Strategic Positioning;
Corporate Entrepreneurship;
Corporate Strategy;
Business Startups;
Strategic Planning;
Competitive Strategy;
Health Industry;
United States
Fuller, Joseph B., David J. Collis, and Matthew G. Preble. "Intrapreneurship at DaVita HealthCare Partners." Harvard Business School Case 315-046, February 2015. (Revised June 2017.)
- Article
Time-driven Activity-based Costing of Multivessel Coronary Artery Bypass Grafting across National Boundaries to Identify Improvement Opportunities: Study Protocol
By: F. Erhun, B. Mistry, T. Platcheck, A. Milstein, V.G. Narayanan and R. S. Kaplan
Coronary artery bypass graft (CABG) surgery is a common treatment for coronary artery disease—a disease that affects over 10% of US adults and is a major cause of morbidity and mortality. In 2005, the mean cost for a CABG procedure among Medicare beneficiaries in the...
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Keywords:
Activity Based Costing and Management;
Health Disorders;
Health Care and Treatment;
United States;
India
Erhun, F., B. Mistry, T. Platcheck, A. Milstein, V.G. Narayanan, and R. S. Kaplan. "Time-driven Activity-based Costing of Multivessel Coronary Artery Bypass Grafting across National Boundaries to Identify Improvement Opportunities: Study Protocol." BMJ Open 5, no. 8 (2015).
- October 2014 (Revised September 2017)
- Case
The National Football League and Brain Injuries
By: Richard G. Hamermesh and Matthew G. Preble
The National Football League (NFL) was both the most popular spectator sport in the U.S. and a major economic entity, taking in roughly $10 billion a year in revenue. However through the early twenty-first century, an increased understanding of the long-term effects of...
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Keywords:
Employee Safety;
Safety;
Employees;
Sports;
Health;
Ethics;
Sports Industry;
United States
Hamermesh, Richard G., and Matthew G. Preble. "The National Football League and Brain Injuries." Harvard Business School Case 815-071, October 2014. (Revised September 2017.)
- September 2014 (Revised May 2017)
- Case
Fresno's Social Impact Bond for Asthma
By: John A. Quelch and Margaret L. Rodriguez
In 2014, Social Impact Bonds (SIBs) were quickly gaining popularity as an investment vehicle which joined together private investors and nonprofits to tackle social issues. Although numerous SIB projects and proposals had cropped up across the U.S. following the launch...
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Keywords:
Social Enterprise;
Health Care;
Marketing;
Bonds;
Financing;
Asthma;
Air Pollution;
Air Quality;
Chronic Disease;
Public Health;
Health;
Health Care and Treatment;
Finance;
Health Industry;
Financial Services Industry;
United States
Quelch, John A., and Margaret L. Rodriguez. "Fresno's Social Impact Bond for Asthma." Harvard Business School Case 515-028, September 2014. (Revised May 2017.)
- April 2014 (Revised March 2018)
- Case
Texas Children's Hospital: Congenital Heart Disease Care
By: Michael E. Porter, Justin M. Bachmann and Zachary C. Landman
In 2014, Dr. Charles D. Fraser Jr., Surgeon-in-Chief of Texas Children's Hospital in Houston, was contemplating the future direction of the congenital heart disease program. The nation's largest pediatric hospital, Texas Children's was ranked by U.S. News & World...
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Keywords:
Health Care;
Congenital Heart Disease;
Integrated Practice Units;
Health Care and Treatment;
Outcome or Result;
Measurement and Metrics;
Performance Improvement;
Health Industry;
United States;
Texas
Porter, Michael E., Justin M. Bachmann, and Zachary C. Landman. "Texas Children's Hospital: Congenital Heart Disease Care." Harvard Business School Case 714-507, April 2014. (Revised March 2018.)
- March 2014
- Editorial
Limits on Use of Health Economic Assessments for Rare Diseases
By: Hanna I. Hyry, Ariel Dora Stern, Jonathan CP Roos and Timothy M. Cox
Funding of expensive treatments for rare ('orphan') diseases is contentious. These agents fare poorly on 'efficiency' or health economic measures, such as the QALY, because of high cost and frequently poor gains in quality of life and survival. We show that...
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Hyry, Hanna I., Ariel Dora Stern, Jonathan CP Roos, and Timothy M. Cox. "Limits on Use of Health Economic Assessments for Rare Diseases." hcu016. QJM: An International Journal of Medicine 107, no. 3 (March 2014): 241–245.
- January 2014 (Revised March 2014)
- Case
Cancer Screening in Japan: Market Research and Segmentation
By: John A. Quelch and Margaret L. Rodriguez
Since founding CancerScan in 2008, Jun Fukuyoshi and Yoshiki Ishikawa had helped to improve cancer screening rates in Japan. Between 2005 and 2007, awareness of breast cancer in Japan rose from 55% to 70%, but the incidence of breast cancer screenings remained...
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Quelch, John A., and Margaret L. Rodriguez. "Cancer Screening in Japan: Market Research and Segmentation." Harvard Business School Case 514-057, January 2014. (Revised March 2014.)
- 2014
- Chapter
Disease Surveillance, Case Study
By: Skyler Speakman, Sriram Somanchi, Edward McFowland III and Daniel B. Neill
Speakman, Skyler, Sriram Somanchi, Edward McFowland III, and Daniel B. Neill. "Disease Surveillance, Case Study." In Encyclopedia of Social Network Analysis and Mining, edited by Reda Alhajj and Jon Rokne, 380–385. New York: Springer, 2014.
- September 2013
- Case
Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired
By: Rosabeth Moss Kanter, Juliane Calingo Schwetz and Patricia Bissett Higgins
In July 2012, retired United States Army Major General Gale Pollock created Elevivo, a venture that worked on developing a comprehensive disease management software system to support the growing number of visually impaired individuals by providing them with tailored...
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Keywords:
United States;
Health Care;
Health Care Education;
Insurance Companies;
Disease Management;
Technology;
Military;
Leadership Skills;
Health;
Health Care and Treatment;
Education;
Insurance;
Information Technology;
Entrepreneurship;
Leadership;
Information Technology Industry;
Health Industry;
United States
- 2013
- Case
Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired
By: Rosabeth M. Kanter, Juliane Calingo Schwetz and Patricia Bissett Higgins
In July 2012, retired United States Army Major General Gale Pollock created Elevivo, a venture that worked on developing a comprehensive disease management software system to support the growing number of visually impaired individuals by providing them with tailored...
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Keywords:
Disease Management;
Health;
Health Care and Treatment;
Education;
Information Technology;
Insurance;
Entrepreneurship;
Leadership;
Information Technology Industry;
Health Industry;
United States
Kanter, Rosabeth M., Juliane Calingo Schwetz, and Patricia Bissett Higgins. "Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired." Harvard Business Publishing Case 314-029, 2013.
- Article
Fast Generalized Subset Scan for Anomalous Pattern Detection
By: Edward McFowland III, Skyler Speakman and Daniel B. Neill
We propose Fast Generalized Subset Scan (FGSS), a new method for detecting anomalous patterns in general categorical data sets. We frame the pattern detection problem as a search over subsets of data records and attributes, maximizing a nonparametric scan statistic...
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Keywords:
Pattern Detection;
Anomaly Detection;
Knowledge Discovery;
Bayesian Networks;
Scan Statistics;
Analytics and Data Science
McFowland III, Edward, Skyler Speakman, and Daniel B. Neill. "Fast Generalized Subset Scan for Anomalous Pattern Detection." Art. 12. Journal of Machine Learning Research 14 (2013): 1533–1561.
- Article
Fast Subset Scan for Multivariate Spatial Biosurveillance
By: Daniel B. Neill, Edward McFowland III and Huanian Zheng
We present new subset scan methods for multivariate event detection in massive space-time datasets. We extend the recently proposed 'fast subset scan' framework from univariate to multivariate data, enabling computationally efficient detection of irregular space-time...
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Neill, Daniel B., Edward McFowland III, and Huanian Zheng. "Fast Subset Scan for Multivariate Spatial Biosurveillance." Statistics in Medicine 32, no. 13 (June 15, 2013): 2185–2208.