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- People (1)
- News (86)
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- September 2017 (Revised July 2023)
- Case
Adaptive Platform Trials: The Clinical Trial of the Future?
By: Ariel D. Stern and Sarah Mehta
In July 2017, Dr. Brian M. Alexander, president and CEO of the AGILE Research Foundation, was preparing to launch a new type of clinical trial—an adaptive platform trial—to study potential therapies for glioblastoma (GBM), an aggressive form of brain cancer....
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Keywords:
Clinical Trials;
Cancer;
Adaptive Platform Trials;
Platform Trials;
Adaptive Trials;
Glioblastoma;
Health;
Health Care and Treatment;
Health Testing and Trials;
Business Strategy;
Innovation Strategy;
Health Industry;
United States
Stern, Ariel D., and Sarah Mehta. "Adaptive Platform Trials: The Clinical Trial of the Future?" Harvard Business School Case 618-025, September 2017. (Revised July 2023.)
- July 2021
- Supplement
Adaptive Platform Trials: The Clinical Trial of the Future? (C)
By: Ariel D. Stern and Sarah Mehta
This (C) case provides an update on the work of the Global Coalition for Adaptive Research (GCAR) and also illustrates how adaptive platform trials can nimbly respond to a global pandemic.
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Keywords:
Clinical Trials;
Drug Trials;
Drug Testing;
Cancer Trials;
Glioblastoma;
Platform Trials;
Adaptive Trials;
Adaptive Platform Trials;
Health Testing and Trials;
Health Care and Treatment;
Business Strategy;
Health Industry;
United States
Stern, Ariel D., and Sarah Mehta. "Adaptive Platform Trials: The Clinical Trial of the Future? (C)." Harvard Business School Supplement 622-012, July 2021.
- March 2018
- Teaching Note
Adaptive Platform Trials: The Clinical Trial of the Future?
By: Ariel D. Stern and Sarah Mehta
This teaching note provides guidance and recommendations for teaching HBS Case No. 618-025, entitled “Adaptive Platform Trials: The Clinical Trial of the Future?”
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- September 2019
- Supplement
Adaptive Platform Trials: The Clinical Trial of the Future? (B)
By: Ariel D. Stern and Sarah Mehta
This case provides an update to the (A) case, which introduces students to adaptive platform trials, an ambitious, more efficient type of clinical trial that increases access to therapies. The (A) case centers on Dr. Brian Alexander’s efforts to launch an adaptive...
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Keywords:
Clinical Trials;
Drug Trials;
Drug Testing;
Cancer Trials;
Glioblastoma;
Platform Trials;
Adaptive Trials;
Adaptive Platform Trials;
Health Testing and Trials;
Health Care and Treatment;
Financing and Loans;
Business Strategy;
Health Industry;
United States
Stern, Ariel D., and Sarah Mehta. "Adaptive Platform Trials: The Clinical Trial of the Future? (B)." Harvard Business School Supplement 620-001, September 2019.
- October 2019
- Article
Adaptive Platform Trials: Definition, Design, Conduct and Reporting Considerations
By: Derek C. Angus, Brian M. Alexander, Scott Berry, Meredith Buxton, Roger Lewis, Melissa Paoloni, Steven A. R. Webb, Steven Arnold, Anna Barker, Donald A. Berry, Marc J. M. Bonten, Mary Brophy, Christopher Butler, Timothy F. Cloughesy, Lennie P. G. Derde, Laura J. Esserman, Ryan Ferguson, Louis Fiore, Sarah C. Gaffey, J. Michael Gaziano, Kathy Giusti, Herman Goossens, Stephane Heritier, Bradley Hyman, Michael Krams, Kay Larholt, Lisa M. LaVange, Philip Lavori, Andrew W. Lo, Alexander J. London, Victoria Manax, Colin McArthur, Genevieve O’Neill, Giovanni Parmigiani, Jane Perlmutter, Elizabeth A. Petzold, Craig Ritchie, Kathryn M. Rowan, Christopher W. Seymour, Nathan I. Shapiro, Diane M. Simeone, Bradley Smith, Bradley Spellberg, Ariel Dora Stern, Lorenzo Trippa, Mark Trusheim, Kert Viele, Patrick Y. Wen and Janet Woodcock
Researchers, clinicians, policymakers, and patients are increasingly interested in questions about therapeutic interventions that are difficult or costly to answer with traditional, free-standing, parallel-group randomized controlled trials (RCTs). Examples include...
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Angus, Derek C., Brian M. Alexander, Scott Berry, Meredith Buxton, Roger Lewis, Melissa Paoloni, Steven A. R. Webb, Steven Arnold, Anna Barker, Donald A. Berry, Marc J. M. Bonten, Mary Brophy, Christopher Butler, Timothy F. Cloughesy, Lennie P. G. Derde, Laura J. Esserman, Ryan Ferguson, Louis Fiore, Sarah C. Gaffey, J. Michael Gaziano, Kathy Giusti, Herman Goossens, Stephane Heritier, Bradley Hyman, Michael Krams, Kay Larholt, Lisa M. LaVange, Philip Lavori, Andrew W. Lo, Alexander J. London, Victoria Manax, Colin McArthur, Genevieve O’Neill, Giovanni Parmigiani, Jane Perlmutter, Elizabeth A. Petzold, Craig Ritchie, Kathryn M. Rowan, Christopher W. Seymour, Nathan I. Shapiro, Diane M. Simeone, Bradley Smith, Bradley Spellberg, Ariel Dora Stern, Lorenzo Trippa, Mark Trusheim, Kert Viele, Patrick Y. Wen, and Janet Woodcock. "Adaptive Platform Trials: Definition, Design, Conduct and Reporting Considerations." Nature Reviews: Drug Discovery 18, no. 10 (October 2019): 797–807.
- March 2022
- Article
From Proprietary to Collective Governance: How Do Platform Participation Strategies Evolve?
By: Siobhan O'Mahony and Rebecca Karp
When platform leaders change the rules guiding who can access and control a platform, the strategies of those who create value from the platform can be upended. Little research examines how platform participants adapt their strategies when a platform leader changes the...
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Keywords:
Platform Governance;
Access;
Crowdsourcing;
Applications and Software;
Employees;
Leadership Style;
Cybersecurity;
Risk Management
O'Mahony, Siobhan, and Rebecca Karp. "From Proprietary to Collective Governance: How Do Platform Participation Strategies Evolve?" Strategic Management Journal 43, no. 3 (March 2022): 530–562.
- November 2015
- Article
Multi-Sided Platforms
By: Andrei Hagiu and Julian Wright
We study the economic tradeoffs that drive organizations to position themselves closer to or further away from a multi-sided platform (MSP) business model, relative to three traditional alternatives: vertically integrated firms, resellers or input suppliers. These...
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Hagiu, Andrei, and Julian Wright. "Multi-Sided Platforms." International Journal of Industrial Organization 43 (November 2015): 162–174.
- 2015
- Working Paper
Multi-Sided Platforms
By: Andrei Hagiu and Julian Wright
We study the economic tradeoffs that drive organizations to position themselves closer to or further away from a multi-sided platform (MSP) business model, relative to three traditional alternatives: vertically integrated firms, resellers or input suppliers. These...
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Hagiu, Andrei, and Julian Wright. "Multi-Sided Platforms." Harvard Business School Working Paper, No. 15-037, November 2014. (Revised March 2015.)
- October 2013 (Revised December 2013)
- Case
Intuit QuickBooks: From Product to Platform
By: Andrei Hagiu and Elizabeth J. Altman
This case focuses on the challenges and opportunities faced by a successful incumbent organization attempting to transform a large portion of its business from a traditionally product-centric operating mode to a platform-based one that leverages network effects to...
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Keywords:
Business Model;
Organizational Change and Adaptation;
Digital Platforms;
Competitive Advantage;
Network Effects;
Consumer Products Industry
Hagiu, Andrei, and Elizabeth J. Altman. "Intuit QuickBooks: From Product to Platform." Harvard Business School Case 714-433, October 2013. (Revised December 2013.)
- January 2021 (Revised August 2021)
- Case
ByteDance: TikTok and the Trials of Going Viral
By: William C. Kirby and John P. McHugh
In 2020, TikTok became the most valuable start-up ever. The short-form, video-sharing social media platform emerged as the crown jewel of the Chinese technology firm ByteDance, realizing 850 million monthly users and an estimated worth of $180 billion. However, a...
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Keywords:
China;
Technology;
Startup;
Start-up;
International Strategy;
Global Strategy And Leadership;
Innovation;
Political Risk;
Regulations;
Trump;
Foreign Policy;
Foreign Investment;
Chinese Internet Market;
Global Strategy;
Crisis Management;
Risk and Uncertainty;
Entrepreneurship;
Globalized Economies and Regions;
Government Legislation;
Innovation and Management;
Governing Rules, Regulations, and Reforms;
Internet and the Web;
Social Media;
Technology Industry;
China;
United States
Kirby, William C., and John P. McHugh. "ByteDance: TikTok and the Trials of Going Viral." Harvard Business School Case 321-110, January 2021. (Revised August 2021.)
- June 2023
- Case
ByteDance: TikTok and the Trials of Going Viral in 2023
By: William C. Kirby, Noah B. Truwit and John P. McHugh
In March 2023, Chew, with an army of well-paid U.S. lobbyists and TikTok creators, descended on Washington. In his testimony, he planned to highlight the 150 million daily active American users on TikTok and how the platform had benefitted small business owners and...
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- August 2020 (Revised November 2020)
- Case
Gogoro: From Electric Scooter to Energy Platform
By: Tarun Khanna and Billy Chan
The founder of Gogoro had always wanted to revolutionize the energy market from day one since he started the electric scooter business that featured an innovative battery swapping technology. Over the course of five years, he had developed a premium line of electric...
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Keywords:
Entrepreneurship;
Information Technology;
Energy;
Organizational Change and Adaptation;
Strategy;
Taiwan
Khanna, Tarun, and Billy Chan. "Gogoro: From Electric Scooter to Energy Platform." Harvard Business School Case 721-379, August 2020. (Revised November 2020.)
- 05 Nov 2021
- Op-Ed
How to Tap the Talent Automated HR Platforms Miss
As the global staffing shortage grinds on, corporate recruiters everywhere are relying on their online hiring platforms and automated systems to deliver the candidates they need. Too often, these tools will fail them, sidelining many qualified workers in the process....
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Keywords:
by Joseph B. Fuller
- 2014
- Working Paper
Product to Platform Transitions: Organizational Identity Implications
By: Elizabeth J. Altman and Mary Tripsas
Organizations are increasingly recognizing that value they once derived from offering standalone products can be significantly enhanced if they transition to platform-based businesses that harness the innovative capabilities of complementors. While the competitive...
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Keywords:
Organizational Change;
Organizational Identity;
Ecosystems;
Complementors;
Managing Innovation;
Organizational Change and Adaptation;
Multi-Sided Platforms;
Innovation and Management;
Organizational Culture
Altman, Elizabeth J., and Mary Tripsas. "Product to Platform Transitions: Organizational Identity Implications." Harvard Business School Working Paper, No. 14-045, December 2013. (Revised September 2014.)
- December 2011 (Revised April 2012)
- Case
Transforming Verizon: A Platform for Change
By: Rosabeth Moss Kanter and Matthew Bird
A new CEO steps into the shoes of his long-time predecessor who had created the U.S. telecommunications giant via a series of acquisitions and, before departing, had initiated the company's strategic repositioning. The new CEO reflected on Verizon's recent successes,...
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Keywords:
Organizational Change and Adaptation;
Organizational Culture;
Globalized Firms and Management;
Groups and Teams;
Telecommunications Industry
Kanter, Rosabeth Moss, and Matthew Bird. "Transforming Verizon: A Platform for Change." Harvard Business School Case 312-082, December 2011. (Revised April 2012.)
- 2019
- Book
The Business of Platforms: Strategy in the Age of Digital Competition, Innovation, and Power
By: Michael A. Cusumano, Annabelle Gawer and David B. Yoffie
The Business of Platforms explores the strategic, economic, and technology management challenges of digital platform businesses. We have five major themes in the book: 1) The world’s most valuable companies are all platforms, in part because platforms have...
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Keywords:
Strategy;
Technology;
Platform;
Internet and the Web;
Management;
Competitive Strategy;
Digital Platforms
Cusumano, Michael A., Annabelle Gawer, and David B. Yoffie. The Business of Platforms: Strategy in the Age of Digital Competition, Innovation, and Power. Harper Business, 2019.
- Article
Effect of Different Financial Incentive Structures on Promoting Physical Activity Among Adults: A Randomized Clinical Trial
By: Chethan Bachireddy, Andrew Joung, Leslie K. John, Francesca Gino, Bradford Tuckfield, Luca Foschini and Katherine L. Milkman
Importance: Few adults engage in recommended levels of physical activity. Financial incentives can promote physical activity, but little is known about how their structure influences their effectiveness; for example, whether incentives are more effective if they are...
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Bachireddy, Chethan, Andrew Joung, Leslie K. John, Francesca Gino, Bradford Tuckfield, Luca Foschini, and Katherine L. Milkman. "Effect of Different Financial Incentive Structures on Promoting Physical Activity Among Adults: A Randomized Clinical Trial." JAMA Network Open 2, no. 8 (August 2019): 1–13.
- Article
Efficiencies and Regulatory Shortcuts: How Should We Regulate Companies like Airbnb and Uber?
By: Benjamin Edelman and Damien Geradin
New software platforms use modern information technology, including full-featured web sites and mobile apps, to allow service providers and consumers to transact with relative ease and increased trust. These platforms provide notable benefits including reducing...
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Keywords:
Platforms;
Regulation;
Sharing Economy;
Uber;
Airbnb;
Universal Service;
Insurance;
Market Platforms;
Service Delivery;
Software;
Service Industry
Edelman, Benjamin, and Damien Geradin. "Efficiencies and Regulatory Shortcuts: How Should We Regulate Companies like Airbnb and Uber?" Stanford Technology Law Review 19, no. 2 (2016): 293–328.
- February 2021
- Article
Trust and Disintermediation: Evidence from an Online Freelance Marketplace
By: Grace Gu and Feng Zhu
As an intermediary improves trust between the two sides of its market to facilitate matching and transactions, it faces an increased risk of disintermediation: with sufficient trust, the two sides may circumvent the intermediary to avoid the intermediary’s fees. In...
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Keywords:
Disintermediation;
Intermediaries;
Online Marketplace;
Platform Strategy;
Trust;
Marketplace Matching;
Digital Platforms
Gu, Grace, and Feng Zhu. "Trust and Disintermediation: Evidence from an Online Freelance Marketplace." Management Science 67, no. 2 (February 2021): 794–807.
- Article
The Translucent Hand of Managed Ecosystems: Engaging Communities for Value Creation and Capture
By: Elizabeth J. Altman, Frank Nagle and Michael Tushman
Management research has increasingly explored the domains of ecosystems, platforms, and open/user/distributed innovation—governance structures focused on engaging with external communities. While these research areas include substantial empirical and theoretical work...
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Keywords:
Ecosystems;
Platforms;
Open And User Innovation Strategy;
Capabilities;
Governance;
Innovation Strategy;
Organizational Change and Adaptation;
Value Creation
Altman, Elizabeth J., Frank Nagle, and Michael Tushman. "The Translucent Hand of Managed Ecosystems: Engaging Communities for Value Creation and Capture." Academy of Management Annals 16, no. 1 (January 2022): 70–101.