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All HBS Web
(115,785)
- Faculty Publications (145)
- 2021
- Working Paper
Development of CAR-T Therapies: Case Histories of Significant Medical Advances
By: Amar Bhidé and Srikant M. Datar
In 2017, the US Food and Drug Administration (FDA) approved an immunotherapeutic treatment, called CAR-T therapy, for two kinds of blood cancers—acute leukemia (ALL) and a lymphoma. We describe 1) how CAR-T works; 2) the foundational advances and discoveries; 3)...
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Keywords:
Immunotherapy;
Health Care and Treatment;
Innovation and Invention;
Research and Development;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, and Srikant M. Datar. "Development of CAR-T Therapies: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 21-035, August 2020. (Revised May 2021.)
- July 2020
- Case
Applying Data Science and Analytics at P&G
By: Srikant M. Datar, Sarah Mehta and Paul Hamilton
Set in December 2019, this case explores how P&G has applied data science and analytics to cut costs and improve outcomes across its business units. The case provides an overview of P&G’s approach to data management and governance, and reviews the challenges associated...
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Keywords:
Data Science;
Analytics;
Analysis;
Information;
Information Management;
Information Types;
Innovation and Invention;
Strategy;
Analytics and Data Science;
Consumer Products Industry;
United States;
Ohio
Datar, Srikant M., Sarah Mehta, and Paul Hamilton. "Applying Data Science and Analytics at P&G." Harvard Business School Case 121-006, July 2020.
- 2021
- Working Paper
Cephalosporins: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant Datar and Katherine Stebbins
Our case history describes the development of three generations of cephalosporins—antibiotics that have significantly reduced hospital infections. After providing an overview of antibiotic development and its challenges we describe how: 1) Early (pre-cephalosporin)...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant Datar, and Katherine Stebbins. "Cephalosporins: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-133, July 2020. (Revised May 2021.)
- 2021
- Working Paper
SSRIs and Non-SSRIs (through 1999): Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Our case history describes the development of Prozac, a blockbuster drug that transformed the treatment of depression – and became a cultural phenomenon in the United States. Specifically, we chronicle the: 1) prior treatments for depression and the research that...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "SSRIs and Non-SSRIs (through 1999): Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-135, July 2020. (Revised June 2021.)
- 2021
- Working Paper
Tamoxifen: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant Datar and Katherine Stebbins
Our case history describes the development of tamoxifen, considered a “gold standard” treatment for millions of breast cancer patients. Specifically, we describe breast cancer treatments prior to tamoxifen’s development; the initial development of tamoxifen from 1960...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation and Invention;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant Datar, and Katherine Stebbins. "Tamoxifen: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-134, July 2020. (Revised May 2021.)
- 2021
- Working Paper
Coronary Artery Bypass Grafting: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Fabio Villa
We describe how Coronary Artery Bypass Grafting (CABG, or more popularly, “bypass”) operations revolutionized the treatment of coronary disease (that can produce fatal heart attacks and debilitating angina). We first provide a simplified overview of coronary disease...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Fabio Villa. "Coronary Artery Bypass Grafting: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-010, July 2019. (Revised May 2021.)
- 2021
- Working Paper
Computed Tomography: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how Computed Tomography (CT) scanners—that combine x-rays and computers to image soft tissues of the brain and other organs—have become a widely used diagnostic tool. Specifically, we chronicle the: 1) the initial development of CT technology and markets...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Computed Tomography: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-004, July 2019. (Revised May 2021.)
- 2021
- Working Paper
Development of Ultrasound Scanning: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how efforts on multiple fronts, including advocacy, training and technological development made ultrasound the second most used diagnostic imaging technology (after X-rays). Specifically, we chronicle: 1) ultrasound’s development and introduction in the...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Development of Ultrasound Scanning: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-003, July 2019. (Revised May 2021.)
- 2021
- Working Paper
Eradicating Helicobacter Pylori Infections to Treat Ulcers: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how a chance discovery of bacteria that infect stomach linings completely changed how physicians treat ulcers. Specifically, we chronicle how: 1) two Australian physicians brought the bacterial infection to the world’s attention and challenged the...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Eradicating Helicobacter Pylori Infections to Treat Ulcers: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-006, July 2019. (Revised May 2021.)
- 2021
- Working Paper
Gastrointestinal Endoscopy: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how endoscopy transformed the diagnosis of ulcers, cancerous polyps and other diseases of the alimentary canal and enabled “minimally invasive” surgeries to treat such diseases. Specifically, we chronicle how: 1) flexible glass fiber instruments in the...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Gastrointestinal Endoscopy: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-005, July 2019. (Revised May 2021.)
- 2021
- Working Paper
HIV Tests and AIDS Treatments: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how a diverse cast of characters including public health organizations, research laboratories, for-profit health care companies, activists and regulators, rolled back the outbreak of HIV/AIDS in just fifteen years. Moreover, as the case history shows, a...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "HIV Tests and AIDS Treatments: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-007, July 2019. (Revised May 2021.)
- 2021
- Working Paper
Laparoscopy: Case Histories of Significant Medical Advances
By: Amar Bhidé, Caitlin N. Bowler and Srikant M. Datar
We describe how operations through laparoscopes—tubular instruments inserted into abdominal cavities—revolutionized gynecological and other surgeries inside the abdomen such as gall bladder removal. Specifically, we chronicle the: 1) foundational technologies and...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Caitlin N. Bowler, and Srikant M. Datar. "Laparoscopy: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-008, July 2019. (Revised May 2021.)
- 2021
- Working Paper
Magnetic Resonance Imaging: Case Histories of Significant Medical Advances
By: Srikant M. Datar, Amar Bhidé and Katherine Stebbins
We describe how and why Magnetic Resource Imaging (MRI) came to complement – and partially replace -- computed tomography (CT) imaging of soft tissue. Specifically we chronicle: 1) the development of foundational techniques and prototypes (through the 1970s); 2)...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Datar, Srikant M., Amar Bhidé, and Katherine Stebbins. "Magnetic Resonance Imaging: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-001, July 2019. (Revised June 2021.)
- 2021
- Working Paper
Mammography: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how the development of x-ray-based techniques and equipment (“mammography”) lead to widespread screening for breast cancer and enabled “minimally invasive” biopsies of breast tumors. Specifically, we chronicle how: 1) the protocols and equipment, developed...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Mammography: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-002, July 2019. (Revised May 2021.)
- May 2019
- Teaching Note
Data Science at Target
By: Srikant M. Datar and Caitlin N. Bowler
Teaching Note for HBS No. 118-016.
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- April 2019
- Teaching Note
The Oakland Athletics: Strategy & Metrics for a Budget
By: Srikant M. Datar and Caitlin N. Bowler
Teaching Note for HBS No. 118-010.
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- January 2019
- Case
Philips' Connected Baby Bottle
By: Rajiv Lal, Srikant M. Datar and Caitlin N. Bowler
Keywords:
Smart Connected Products
Lal, Rajiv, Srikant M. Datar, and Caitlin N. Bowler. "Philips' Connected Baby Bottle." Harvard Business School Case 519-020, January 2019.
- November 2018
- Case
frog design
By: Srikant M. Datar and Caitlin N. Bowler
The case follows the genesis and development of Palo, a radical urban communications hub designed to replace payphone booths on Manhattan’s city streets, through a joint venture between frog design and a venture-backed firm LQD WiFi. The case explores the complexity of...
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Keywords:
Innovation;
Prototyping;
User Experience Design;
Design Heuristics;
Telecommunications;
Urban Systems;
Communication Technology;
Urban Scope;
Innovation and Invention;
Design;
Product Development
Datar, Srikant M., and Caitlin N. Bowler. "frog design." Harvard Business School Multimedia/Video Case 118-707, November 2018.
- October 2018
- Case
Fundraising at St. Camillus Hospital
By: Srikant M. Datar and Caitlin N. Bowler
St. Camillus is a fictional non-profit hospital in rural Maine facing a serious budget deficit. As Director of Marketing, Victoria Stern is building a team to modernize the hospital fundraising efforts. An interview with a promising candidate, who is also a digital...
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Keywords:
Data Analysis;
Data Privacy;
Data Governance;
Non-profit;
Health Care;
Fundraising;
Data Security;
Analytics and Data Science;
Safety;
Governance;
Ethics;
Health Care and Treatment;
Cybersecurity
Datar, Srikant M., and Caitlin N. Bowler. "Fundraising at St. Camillus Hospital." Harvard Business School Case 119-027, October 2018.