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      • January 2023
      • Case

      Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery

      By: Regina Herzlinger and Brian Walker
      What should a successful executive (HBS Baker Scholar) assess as her next move as the CEO of a firm with a promising and yet uncertain new drug? Amy Burroughs’ mandate to successfully commercialize Cleave Therapeutics’ drug for a cancer with no current successful...  View Details
      Keywords: Product Development; Leadership; Health Testing and Trials; Research and Development; Risk and Uncertainty; Financial Condition; Partners and Partnerships; Pharmaceutical Industry
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      Herzlinger, Regina, and Brian Walker. "Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery." Harvard Business School Case 323-045, January 2023.
      • 2023
      • Chapter

      Business, Climate Change and the Anthropocene

      By: Andrew J. Hoffman and Sukanya Roy
      This chapter will assess climate change as a concern for business, both as a stand-alone issue and as part of the broader shift that scientists are calling the Anthropocene. It will begin by examining the extent to which the market – comprised of corporations, the...  View Details
      Keywords: Climate Change; Problems and Challenges; Mission and Purpose
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      Hoffman, Andrew J., and Sukanya Roy. "Business, Climate Change and the Anthropocene." Chap. 23 in Corporate Sustainability: Managing Responsible Business in a Globalised World, edited by Andreas Rasche, Mette Morsing, Jeremy Moon, and Arno Kourula, 484–505. Cambridge University Press, 2023.
      • May 2022
      • Case

      Timnit Gebru: 'SILENCED No More' on AI Bias and The Harms of Large Language Models

      By: Tsedal Neeley and Stefani Ruper
      Dr. Timnit Gebru—a leading artificial intelligence (AI) computer scientist and co-lead of Google’s Ethical AI team—was messaging with one of her colleagues when she saw the words: “Did you resign?? Megan sent an email saying that she accepted your resignation.” Heart...  View Details
      Keywords: Ethics; Employment; Corporate Social Responsibility and Impact; Technological Innovation
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      Neeley, Tsedal, and Stefani Ruper. "Timnit Gebru: 'SILENCED No More' on AI Bias and The Harms of Large Language Models." Harvard Business School Case 422-085, May 2022.
      • 2022
      • Working Paper

      The Disagreement Problem in Explainable Machine Learning: A Practitioner's Perspective

      By: Satyapriya Krishna, Tessa Han, Alex Gu, Javin Pombra, Shahin Jabbari, Steven Wu and Himabindu Lakkaraju
      As various post hoc explanation methods are increasingly being leveraged to explain complex models in high-stakes settings, it becomes critical to develop a deeper understanding of if and when the explanations output by these methods disagree with each other, and how...  View Details
      Keywords: AI and Machine Learning; Analytics and Data Science; Mathematical Methods
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      Krishna, Satyapriya, Tessa Han, Alex Gu, Javin Pombra, Shahin Jabbari, Steven Wu, and Himabindu Lakkaraju. "The Disagreement Problem in Explainable Machine Learning: A Practitioner's Perspective." Working Paper, 2022.
      • February 2022 (Revised September 2022)
      • Case

      InstaDeep: AI Innovation Born in Africa (A)

      By: Shikhar Ghosh and Esel Çekin
      Karim Beguir and Zohra Slim were the co-founders of InstaDeep, a deep tech startup focusing on artificial intelligence (AI) solutions. Instadeep was one of the few companies globally that were partnering with DeepMind, an AI subsidiary of Google [Alphabet Inc.]....  View Details
      Keywords: AI; Artificial Intelligence; Entrepreneurship; Operations; Business Subsidiaries; Brands and Branding; Innovation and Invention; Growth and Development Strategy; AI and Machine Learning; Technology Industry; Africa
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      Ghosh, Shikhar, and Esel Çekin. "InstaDeep: AI Innovation Born in Africa (A)." Harvard Business School Case 822-104, February 2022. (Revised September 2022.)
      • February 2022 (Revised July 2022)
      • Supplement

      InstaDeep: AI Innovation Born in Africa (B)

      By: Shikhar Ghosh and Esel Çekin
      Karim Beguir and Zohra Slim were the co-founders of InstaDeep, a deep tech startup focusing on artificial intelligence (AI) solutions. Instadeep was one of the few companies globally that were partnering with DeepMind, an AI subsidiary of Google [Alphabet Inc.]....  View Details
      Keywords: AI; Artificial Intelligence; Entrepreneurship; Operations; Business Subsidiaries; Brands and Branding; Innovation and Invention; Growth and Development Strategy; AI and Machine Learning; Technology Industry; Africa
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      Ghosh, Shikhar, and Esel Çekin. "InstaDeep: AI Innovation Born in Africa (B)." Harvard Business School Supplement 822-105, February 2022. (Revised July 2022.)
      • 2022
      • Chapter

      Sustainability Science and Corporate Cleanup in Community Fields: The Translation, Resistance and Integration Process Model

      By: P. Devereaux Jennings, Maggie Cascadden and Andrew J. Hoffman
      Both practically and theoretically, the sustainability science and corporate operation perspectives often diverge. Overcoming this divergence requires some degree of engagement with organizational field members; not just negotiation, but on-the-ground process work to...  View Details
      Keywords: Environmental Sustainability; Business Processes; Science-Based Business; Research
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      Jennings, P. Devereaux, Maggie Cascadden, and Andrew J. Hoffman. "Sustainability Science and Corporate Cleanup in Community Fields: The Translation, Resistance and Integration Process Model." Chap. 12 in Handbook on the Business of Sustainability: The Organization, Implementation, and Practice of Sustainable Growth, edited by Gerard George, Martine Haas, Havovi Joshi, Anita McGahan, and Paul Tracey, 214–231. Edward Elgar Publishing, 2022.
      • Article

      Megastudies Improve the Impact of Applied Behavioural Science

      By: Katherine L. Milkman, Dena Gromet, Hung Ho, Joseph S. Kay, Timothy W. Lee, Pepi Pandiloski, Yeji Park, Aneesh Rai, Max Bazerman, John Beshears, Lauri Bonacorsi, Colin Camerer, Edward Chang, Gretchen Chapman, Robert Cialdini, Hengchen Dai, Lauren Eskreis-Winkler, Ayelet Fishbach, James J. Gross, Samantha Horn, Alexa Hubbard, Steven J. Jones, Dean Karlan, Tim Kautz, Erika Kirgios, Joowon Klusowski, Ariella Kristal, Rahul Ladhania, Jens Ludwig, George Loewenstein, Barbara Mellers, Sendhil Mullainathan, Silvia Saccardo, Jann Spiess, Gaurav Suri, Joachim H. Talloen, Jamie Taxer, Yaacov Trope, Lyle Ungar, Kevin G. Volpp, Ashley V. Whillans, Jonathan Zinman and Angela L. Duckworth
      Policy-makers are increasingly turning to behavioural science for insights about how to improve citizens’ decisions and outcomes. Typically, different scientists test different intervention ideas in different samples using different outcomes over different time...  View Details
      Keywords: Policy Making; Behavioral Science; Behavior; Change; Decision Making; Policy
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      Milkman, Katherine L., Dena Gromet, Hung Ho, Joseph S. Kay, Timothy W. Lee, Pepi Pandiloski, Yeji Park, Aneesh Rai, Max Bazerman, John Beshears, Lauri Bonacorsi, Colin Camerer, Edward Chang, Gretchen Chapman, Robert Cialdini, Hengchen Dai, Lauren Eskreis-Winkler, Ayelet Fishbach, James J. Gross, Samantha Horn, Alexa Hubbard, Steven J. Jones, Dean Karlan, Tim Kautz, Erika Kirgios, Joowon Klusowski, Ariella Kristal, Rahul Ladhania, Jens Ludwig, George Loewenstein, Barbara Mellers, Sendhil Mullainathan, Silvia Saccardo, Jann Spiess, Gaurav Suri, Joachim H. Talloen, Jamie Taxer, Yaacov Trope, Lyle Ungar, Kevin G. Volpp, Ashley V. Whillans, Jonathan Zinman, and Angela L. Duckworth. "Megastudies Improve the Impact of Applied Behavioural Science." Nature 600, no. 7889 (December 16, 2021): 478–483.
      • November 2021 (Revised May 2022)
      • Case

      QuantumScape's Mission to Revolutionize Energy Storage for a Sustainable Future

      By: William A. Sahlman, Allison M. Ciechanover and Jeff Huizinga
      QuantumScape CEO Jagdeep Singh juggles the many activities required to lead the next-generation battery pioneer. Founded in 2010, QuantumScape’s mission was to develop new “solid-state” car batteries that would improve upon traditional lithium-ion batteries in key...  View Details
      Keywords: Batteries; Electric Vehicles; SPACs; Innovation and Management; Technological Innovation; Science-Based Business; Environmental Sustainability; Auto Industry; Energy Industry; California; San Jose
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      Sahlman, William A., Allison M. Ciechanover, and Jeff Huizinga. "QuantumScape's Mission to Revolutionize Energy Storage for a Sustainable Future." Harvard Business School Case 822-044, November 2021. (Revised May 2022.)
      • Article

      Potentially Long-Lasting Effects of the Pandemic on Scientists

      By: Jian Gao, Yian Yin, Kyle R. Myers, Karim R. Lakhani and Dashun Wang
      Two surveys of principal investigators conducted between April 2020 and January 2021 reveal that while the COVID-19 pandemic’s initial impacts on scientists’ research time seem alleviated, there has been a decline in the rate of initiating new projects. This dimension...  View Details
      Keywords: COVID-19; Scientists; Scientific Research; Health Pandemics; Research; Gender
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      Gao, Jian, Yian Yin, Kyle R. Myers, Karim R. Lakhani, and Dashun Wang. "Potentially Long-Lasting Effects of the Pandemic on Scientists." Art. 6188. Nature Communications 12 (2021).
      • June 2021
      • Case

      uBiome

      By: Thomas R. Eisenmann and Olivia Graham
      uBiome provided clinical tests that sequenced the DNA of human microbiome samples, providing data on health conditions directly to consumers or to prescribing physicians. Founded in 2012, the San Francisco-based startup raised $105 million from top-tier venture capital...  View Details
      Keywords: Business Startups; Crime and Corruption; Insolvency and Bankruptcy
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      Eisenmann, Thomas R., and Olivia Graham. "uBiome." Harvard Business School Case 821-076, June 2021.
      • June 2021
      • Article

      Engineering Serendipity: When Does Knowledge Sharing Lead to Knowledge Production?

      By: Jacqueline N. Lane, Ina Ganguli, Patrick Gaule, Eva C. Guinan and Karim R. Lakhani
      We investigate how knowledge similarity between two individuals is systematically related to the likelihood that a serendipitous encounter results in knowledge production. We conduct a natural field experiment at a medical research symposium, where we exogenously...  View Details
      Keywords: Cognitive Similarity; Innovation; Knowledge Production; Natural Field Experiment; Knowledge Acquisition; Knowledge Sharing; Relationships
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      Lane, Jacqueline N., Ina Ganguli, Patrick Gaule, Eva C. Guinan, and Karim R. Lakhani. "Engineering Serendipity: When Does Knowledge Sharing Lead to Knowledge Production?" Strategic Management Journal 42, no. 6 (June 2021).
      • January 2021
      • Article

      Institutional-Political Scenarios for Anthropocene Society

      By: Andrew J. Hoffman and P. Devereaux Jennings
      Natural scientists have proposed that humankind has entered a new geologic epoch. Termed the “Anthropocene,” this new reality revolves around the central role of human activity in multiple Earth ecosystems. That challenge requires a rethinking of social science...  View Details
      Keywords: Institutional Change; Institutional Theory; Natural Environment; Society; Environmental Sustainability
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      Hoffman, Andrew J., and P. Devereaux Jennings. "Institutional-Political Scenarios for Anthropocene Society." Business & Society 60, no. 1 (January 2021): 57–94.
      • Article

      GitLab: Work Where You Want, When You Want

      By: Prithwiraj Choudhury, Kevin Crowston, Linus Dahlander, Marco S. Minervini and Sumita Raghuram
      GitLab is a software company that works “all remote” at the scale of more than 1,000 employees located in more than 60 countries. GitLab has no physical office and its employees can work from anywhere they choose. Any step of the organizational life of a GitLab...  View Details
      Keywords: New Forms Of Organizing; Remote Work; All Remote; Virtual Organizations; COVID-19; Organizational Design; Employees; Geographic Location; Health Pandemics
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      Choudhury, Prithwiraj, Kevin Crowston, Linus Dahlander, Marco S. Minervini, and Sumita Raghuram. "GitLab: Work Where You Want, When You Want." Art. 23. Journal of Organization Design 9 (2020).
      • October 2020
      • Article

      The Elasticity of Science

      By: Kyle Myers
      This paper identifies the degree to which scientists are willing to change the direction of their work in exchange for resources. Data from the National Institutes of Health are used to estimate how scientists respond to targeted funding opportunities. Inducing a...  View Details
      Keywords: Scientists; Funding; Research; Change
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      Myers, Kyle. "The Elasticity of Science." American Economic Journal: Applied Economics 12, no. 4 (October 2020): 103–134.
      • September 2020
      • Article

      Unequal Effects of the COVID-19 Pandemic on Scientists

      By: Kyle Myers, Wei Yang Tham, Yian Yin, Nina Cohodes, Marie Thursby, Jerry Thursby, Peter Schiffer, Joseph Walsh, Karim R. Lakhani and Dashun Wang
      COVID-19 has not affected all scientists equally. A survey of principal investigators indicates that female scientists, those in the ‘bench sciences’ and, especially, scientists with young children experienced a substantial decline in time devoted to research. This...  View Details
      Keywords: COVID-19; Scientists; Health Pandemics; Gender; Personal Development and Career
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      Myers, Kyle, Wei Yang Tham, Yian Yin, Nina Cohodes, Marie Thursby, Jerry Thursby, Peter Schiffer, Joseph Walsh, Karim R. Lakhani, and Dashun Wang. "Unequal Effects of the COVID-19 Pandemic on Scientists." Nature Human Behaviour 4, no. 9 (September 2020): 880–883.
      • Article

      The Importance of Being Causal

      By: Iavor I Bojinov, Albert Chen and Min Liu
      Causal inference is the study of how actions, interventions, or treatments affect outcomes of interest. The methods that have received the lion’s share of attention in the data science literature for establishing causation are variations of randomized experiments....  View Details
      Keywords: Causal Inference; Observational Studies; Cross-sectional Studies; Panel Studies; Interrupted Time-series; Instrumental Variables
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      Bojinov, Iavor I., Albert Chen, and Min Liu. "The Importance of Being Causal." Harvard Data Science Review 2.3 (July 30, 2020).
      • March 21, 2020
      • Editorial

      When We're Wrong, It's Our Responsibility as Scientists to Say So

      By: Ariella S. Kristal, A. V. Whillans, Max Bazerman, Francesca Gino, Lisa Shu, Nina Mazar and Dan Ariely
      We tried to reproduce our 2012 paper on how to make people report their income more honestly—and we ended up refuting it.  View Details
      Keywords: Responsibility; Outcome or Result
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      Kristal, Ariella S., A. V. Whillans, Max Bazerman, Francesca Gino, Lisa Shu, Nina Mazar, and Dan Ariely. "When We're Wrong, It's Our Responsibility as Scientists to Say So." Scientific American (March 21, 2020).
      • March 2020
      • Article

      Do Managers Matter? A Natural Experiment from 42 R&D Labs in India

      By: Prithwiraj Choudhury, Tarun Khanna and Christos A. Makridis
      We exploit plausibly exogenous variation in the staggered entry of new managers into India’s 42 public R&D labs between 1994 and 2006 to study how alignment between the CEO and middle-level managers affect research productivity. We show that the introduction of new lab...  View Details
      Keywords: Incentives; Innovation; Productivity; Management; Alignment; Research and Development; Innovation and Invention; Performance Productivity; India
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      Choudhury, Prithwiraj, Tarun Khanna, and Christos A. Makridis. "Do Managers Matter? A Natural Experiment from 42 R&D Labs in India." Journal of Law, Economics & Organization 36, no. 1 (March 2020): 47–83.
      • January 2020
      • Case

      The Origins of Bell Labs

      By: Tom Nicholas and John Masko
      In 1947, scientists at Bell Labs invented the transistor—a tiny signal amplifier that would go on to become the fundamental building block of the digital age. But, confounding most traditional economic assumptions, it was not a vigorous startup that made this momentous...  View Details
      Keywords: Business History; Innovation Leadership; Technological Innovation; Patents; Monopoly; Organizational Structure; Competitive Strategy; Telecommunications Industry; Boston; Massachusetts; New York (city, NY)
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      Nicholas, Tom, and John Masko. "The Origins of Bell Labs." Harvard Business School Case 820-081, January 2020.
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