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All HBS Web
(194)
- Faculty Publications (87)
- November 2019 (Revised June 2020)
- Case
Indigo Agriculture: Harnessing Nature
By: Marco Iansiti, Michael W. Toffel and James Barnett
Indigo Agriculture used a digital-enabled research and development (R&D) process to launch its initial product, microbial coatings for agricultural seeds, which increase crop yields while reducing the need for fertilizers. In doing so, the company developed direct...
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Keywords:
Carbon Sequestration;
Operations;
Supply Chain;
Social Enterprise;
Product Development;
Distribution Channels;
Business Strategy;
Digital Platforms;
Environmental Sustainability;
Science-Based Business;
Climate Change;
Agriculture and Agribusiness Industry;
Green Technology Industry;
United States;
Massachusetts
Iansiti, Marco, Michael W. Toffel, and James Barnett. "Indigo Agriculture: Harnessing Nature." Harvard Business School Case 620-024, November 2019. (Revised June 2020.)
- October 2019 (Revised December 2019)
- Supplement
Extend Fertility: Conceiving the Market for Egg Preservation (B)
By: Debora L. Spar and Olivia Hull
Keywords:
Strategy;
Information Technology;
Business Startups;
Entrepreneurship;
Innovation Strategy;
Technological Innovation;
Commercialization;
Science-Based Business;
Marketing Strategy;
Business Plan;
Product Marketing;
Product Launch;
Product Positioning;
Mission and Purpose;
Personal Development and Career;
Social Issues;
Integration;
Health;
Health Industry
Spar, Debora L., and Olivia Hull. "Extend Fertility: Conceiving the Market for Egg Preservation (B)." Harvard Business School Supplement 720-017, October 2019. (Revised December 2019.)
- October 2019 (Revised November 2019)
- Case
C16 Biosciences: Lab-Grown Palm Oil
By: Jeffrey J. Bussgang and Olivia Hull
Synthetic biology start-up C16 Biosciences wants to solve a big problem: replace palm oil, a major contributor to deforestation and climate change, with a lab-grown substitute. CEO Shara Ticku has ambitious plans to supply her lab-grown palm oil to food manufacturers,...
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Keywords:
Science-Based Business;
Environmental Sustainability;
Social Entrepreneurship;
Product Development;
Product Positioning;
Venture Capital;
Strategy;
Decision Making;
Food and Beverage Industry;
Consumer Products Industry
Bussgang, Jeffrey J., and Olivia Hull. "C16 Biosciences: Lab-Grown Palm Oil." Harvard Business School Case 820-008, October 2019. (Revised November 2019.)
- June 2019
- Teaching Note
Zebra Medical Vision
By: Shane Greenstein and Sarah Gulick
Teaching note is meant to accompany Zebra Medical Vision case, which offers a look at a company’s decisions as a small startup competing with other startups and major technology companies. It also demonstrates the challenges faced by a machine learning company working...
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- March 2019
- Case
DayTwo: Going to Market with Gut Microbiome
By: Ayelet Israeli and David Lane
DayTwo is a young Israeli startup that applies research on the gut microbiome and machine learning algorithms to deliver personalized nutritional recommendations to its users in order to minimize blood sugar spikes after meals. After a first year of trial rollout in...
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Keywords:
Start-up Growth;
Startup;
Positioning;
Targeting;
Go To Market Strategy;
B2B2C;
B2B Vs. B2C;
Health & Wellness;
AI;
Machine Learning;
Female Ceo;
Female Protagonist;
Science-based;
Science And Technology Studies;
Ecommerce;
Applications;
DTC;
Direct To Consumer Marketing;
US Health Care;
"USA,";
Innovation;
Pricing;
Business Growth;
Segmentation;
Distribution Channels;
Growth and Development Strategy;
Business Startups;
Science-Based Business;
Health;
Innovation and Invention;
Marketing;
Information Technology;
Business Growth and Maturation;
E-commerce;
Applications and Software;
Health Industry;
Technology Industry;
Insurance Industry;
Information Technology Industry;
Food and Beverage Industry;
Israel;
United States
Israeli, Ayelet, and David Lane. "DayTwo: Going to Market with Gut Microbiome." Harvard Business School Case 519-010, March 2019.
- 2017
- Mimeo
Science for Society: Science and Technology Based Social Entrepreneurship
By: Tarun Khanna, Shashank Shah and Kundan Madireddy
This publication is an outcome of the team's research, engagement and interactions with over 25 science and technology-based social enterprises in India. It provides details on the research process, insightful outcomes and innovative impact.
Throughout the... View Details
Throughout the... View Details
Keywords:
Social Entrepreneurship;
Science-Based Business;
Information Technology;
Business and Community Relations;
India
Khanna, Tarun, Shashank Shah, and Kundan Madireddy. "Science for Society: Science and Technology Based Social Entrepreneurship." Harvard University South Asia Institute, 2017. Mimeo. (This publication is an outcome of a grant from the Tata Trusts.)
- Winter 2017
- Article
Why Big Data Isn't Enough
By: Sen Chai and Willy C. Shih
There is a growing belief that sophisticated algorithms can explore huge databases and find relationships independent of any preconceived hypotheses. But in businesses that involve scientific research and technological innovation, this approach is misguided and...
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Keywords:
Big Data;
Science-based;
Science;
Scientific Research;
Data Analytics;
Data Science;
Data-driven Management;
Data Scientists;
Technological Innovation;
Analytics and Data Science;
Mathematical Methods;
Theory
Chai, Sen, and Willy C. Shih. "Why Big Data Isn't Enough." Art. 58227. MIT Sloan Management Review 58, no. 2 (Winter 2017): 57–61.
- Article
Lessons From Hollywood: A New Approach To Funding R&D
By: Gary P. Pisano and Andrew W. Lo
Companies find it increasingly difficult to justify long-term, risky R&D investments—particularly in science-based fields such as biotechnology, advanced materials, and energy. We argue in this article that the traditional venture model has limits for such investments...
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Keywords:
Financial Innovation;
Financial Strategy;
Project Management;
R&D;
Start-up;
Innovation Strategy;
Business Model;
Research and Development;
Financial Management;
Risk Management;
Strategy
Pisano, Gary P., and Andrew W. Lo. "Lessons From Hollywood: A New Approach To Funding R&D." MIT Sloan Management Review 57, no. 2 (Winter 2016): 47–54.
- November 2016 (Revised November 2016)
- Case
Radial Analytics Probes Post-Acute Care
By: Richard G. Hamermesh and Olivia Hull
Thaddeus Fulford-Jones and Eric Weiss, founders of healthcare technology startup Radial Analytics, have been busy developing a software program designed to save hospitals money and improve patient outcomes by producing customized care plans for patients leaving the...
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Keywords:
Electronic Medical Records;
Electronic Health Records;
Data Science;
Entrepreneurship;
Health Care and Treatment;
Business Model;
Business Startups;
Innovation and Invention;
Growth Management;
Marketing Strategy;
Product Launch;
Product Positioning;
Science-Based Business;
Business Strategy;
Health Industry;
Technology Industry;
Cambridge;
Massachusetts
Hamermesh, Richard G., and Olivia Hull. "Radial Analytics Probes Post-Acute Care." Harvard Business School Case 817-029, November 2016. (Revised November 2016.)
- October 2016 (Revised November 2016)
- Case
Innovating Beyond Ochsner
By: Richard G. Hamermesh and Olivia Hull
The Ochsner Health System has developed a proprietary software tool designed to treat hypertension. Built into the system’s electronic medical records, the Hypertension Digital Medicine program allows patients to record their blood pressure at home and share readings...
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Keywords:
Electronic Medical Records;
Telemedicine;
Hypertension;
High Blood Pressure;
Chronic Disease;
Entrepreneurship;
Health Disorders;
Business Model;
Business Startups;
Innovation and Invention;
Growth Management;
Marketing Strategy;
Product Launch;
Product Positioning;
Science-Based Business;
Business Strategy;
Health Industry;
Technology Industry;
New Orleans;
Louisiana
Hamermesh, Richard G., and Olivia Hull. "Innovating Beyond Ochsner." Harvard Business School Case 817-028, October 2016. (Revised November 2016.)
- October 2016 (Revised November 2018)
- Case
Indigo Agriculture
By: Marco Iansiti, Michael W. Toffel and Christine Snively
Indigo Agriculture had successfully developed and launched its first commercial product, microbe-enhanced cotton seeds, on an accelerated product development timeline. In late 2016, as the company was about to launch its second product, winter wheat, the management...
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Keywords:
Product Development;
Agribusiness;
Science-Based Business;
Operations;
Management;
Agriculture and Agribusiness Industry;
Technology Industry
Iansiti, Marco, Michael W. Toffel, and Christine Snively. "Indigo Agriculture." Harvard Business School Case 617-020, October 2016. (Revised November 2018.)
- October 2016
- Article
Looking Across and Looking Beyond the Knowledge Frontier: Intellectual Distance and Resource Allocation in Science
By: Kevin J. Boudreau, Eva Guinan, Karim R. Lakhani and Christoph Riedl
Selecting among alternative innovative projects is a core management task in all innovating organizations. In this paper, we focus on the evaluation of frontier scientific research projects. We argue that the "intellectual distance" between the knowledge embodied in...
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Keywords:
Knowledge;
Innovation;
Novelty;
Evaluation;
Resource Allocation;
Decision Choices and Conditions;
Innovation and Management;
Science-Based Business;
Experience and Expertise
Boudreau, Kevin J., Eva Guinan, Karim R. Lakhani, and Christoph Riedl. "Looking Across and Looking Beyond the Knowledge Frontier: Intellectual Distance and Resource Allocation in Science." Management Science 62, no. 10 (October 2016).
- February 2016 (Revised September 2017)
- Case
Neurotrack and the Alzheimer's Puzzle
By: Richard G. Hamermesh, Liz Kind and Carin-Isabel Knoop
Elli Kaplan founded Neurotrack in 2012 with a breakthrough noninvasive cognitive diagnostics test that will detect Alzheimer's disease in its earliest pre-symptomatic stages. While the company has gained great traction in the three years since it was started, with no...
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Keywords:
Alzheimer's Disease;
Diagnostics;
Healthcare;
Entrepreneurship;
Health Disorders;
Science-Based Business;
Business Model;
Medical Devices and Supplies Industry;
United States
Hamermesh, Richard G., Liz Kind, and Carin-Isabel Knoop. "Neurotrack and the Alzheimer's Puzzle." Harvard Business School Case 816-072, February 2016. (Revised September 2017.)
- 2015
- Case
Advanced Leadership Pathways: Torsten Thiele and the Global Ocean Trust
By: Rosabeth Moss Kanter and Brian Hoffstein
Following a successful career in finance, Torsten Thiele devoted himself full-time to the challenging cause of ocean conservation and stewardship. In August 2015, Thiele had already come a long way in spearheading initiatives towards the protection of the ocean: from...
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Keywords:
Environment;
Natural Environment;
Environmental Sustainability;
Pollutants;
Science-Based Business;
Climate Change;
Social Enterprise;
Leadership
Kanter, Rosabeth Moss, and Brian Hoffstein. "Advanced Leadership Pathways: Torsten Thiele and the Global Ocean Trust." Harvard Business Publishing Case 316-039, 2015. (Harvard Advanced Leadership Initiative.)
- November 2014
- Teaching Note
Houston We Have a Problem: NASA and Open Innovation (A) and (B)
By: Michael L. Tushman, Hila Lifshitz-Assaf and Kerry Herman
- February 2014
- Case
BGI: Data-driven Research
By: Willy Shih and Sen Chai
BGI has the largest installed gene-sequencing capacity in the world, and to Zhang Gengyun, general manager of the Life Sciences Division, this represented an opportunity to apply his training as a plant breeder and his early career work as a biochemist to improving...
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Keywords:
Genomics;
Gene Sequencing;
Life Sciences;
Plant Breeding;
Human Genome Program;
Beijing Genomics Institute;
BGI;
Rice Genome;
Technological Innovation;
Innovation Strategy;
Research;
Research and Development;
Science;
Genetics;
Science-Based Business;
Strategy;
Commercialization;
Corporate Strategy;
Information Technology;
Applications and Software;
Agriculture and Agribusiness Industry;
Biotechnology Industry;
Food and Beverage Industry;
China;
United States
Shih, Willy, and Sen Chai. "BGI: Data-driven Research." Harvard Business School Case 614-056, February 2014.
- September 2013 (Revised November 2015)
- Case
Living Proof: Are We a Technology Company or a Beauty Company?
By: Willy Shih
Jon Flint came up with the idea of a science-based beauty company while talking with his hairdresser about the problems with typical hair and skin care products. Together with a small team that included Professor Robert Langer of MIT, he committed to assemble a team... View Details
Keywords:
Hair Care;
Personal Care;
Science-based;
R&D;
Innovation and Invention;
Innovation and Management;
Innovation Leadership;
Innovation Strategy;
Technological Innovation;
Marketing;
Marketing Strategy;
Product Marketing;
Product Positioning;
Science-Based Business;
Business Strategy;
Commercialization;
Corporate Strategy;
Technology Platform;
Expansion;
Beauty and Cosmetics Industry;
United States;
Boston;
Cambridge
Shih, Willy. "Living Proof: Are We a Technology Company or a Beauty Company?" Harvard Business School Case 614-013, September 2013. (Revised November 2015.)
- July 2013 (Revised November 2021)
- Module Note
Exploration vs. Exploitation
By: Willy Shih
This module note introduces James March's concept of exploration and exploitation, and the management challenge of balancing the allocation of resources to the two activities in the firm. The note also touches on the O'Reilly and Tushman paper on the ambidextrous...
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Keywords:
Exploration And Exploitation;
Exploitation;
Research;
Scientific Research;
Product Commercialization;
Innovation and Invention;
Innovation and Management;
Innovation Leadership;
Innovation Strategy;
Technological Innovation;
Knowledge Acquisition;
Growth and Development Strategy;
Resource Allocation;
Strategic Planning;
Research and Development;
Science-Based Business;
Corporate Strategy;
Knowledge Sharing;
Biotechnology Industry;
Information Technology Industry;
Manufacturing Industry;
Medical Devices and Supplies Industry;
Pharmaceutical Industry;
Semiconductor Industry;
Technology Industry;
United States
Shih, Willy. "Exploration vs. Exploitation." Harvard Business School Module Note 614-004, July 2013. (Revised November 2021.)
- July 2013
- Case
Novozymes: Establishing the Cellulosic Ethanol Value Chain
By: Willy Shih and Sen Chai
As the world's largest producer of industrial enzymes, Novozymes had invested heavily for many years to bio-engineer enzymes that could break down cellulose into fermentable sugar. In 2010, the company had launched what it thought would become a breakthrough product... View Details
Keywords:
System Complexity;
Industrial Enzymes;
Ethanol;
Collulosic Ethanol;
Fermentation;
Genomics;
Genetic Engineering;
Value Chain;
Assembling Value Chain;
Energy Sources;
Renewable Energy;
Collaborative Innovation and Invention;
Innovation and Management;
Innovation Strategy;
Technological Innovation;
Management;
Growth and Development Strategy;
Industry Growth;
Production;
Research;
Research and Development;
Science;
Genetics;
Natural Environment;
Environmental Sustainability;
Science-Based Business;
Business Strategy;
Commercialization;
Vertical Integration;
Agriculture and Agribusiness Industry;
Biotechnology Industry;
Energy Industry;
Denmark;
United States
Shih, Willy, and Sen Chai. "Novozymes: Establishing the Cellulosic Ethanol Value Chain." Harvard Business School Case 614-001, July 2013.
- January 2013
- Case
Cabot Corporation: The Fuel Cell Decision (A)
By: Willy Shih and Ying Zhou
Managers at Cabot Corporation are faced with deciding the future of its fuel cell program. The (A) case recounts the view of the business manager and the technical project lead, and the (B) case describes the perspective of a senior manager who is the head of the New...
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Keywords:
Technical Decision-making;
Decision-making Process;
Fuel Cells;
Decision Choices and Conditions;
Decisions;
Judgments;
Business Plan;
Business Exit or Shutdown;
Energy Generation;
Energy Sources;
Innovation and Management;
Innovation Strategy;
Technological Innovation;
Research and Development;
Science-Based Business;
Commercialization;
Technology Industry;
Manufacturing Industry;
Massachusetts;
United States
Shih, Willy, and Ying Zhou. "Cabot Corporation: The Fuel Cell Decision (A)." Harvard Business School Case 613-066, January 2013.