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- 2023
- Working Paper
The Political Economy of a 'Miracle Cure': The Case of Nebulized Ibuprofen and Its Diffusion in Argentina
By: Sebastian Calónico, Rafael Di Tella and Juan Cruz Lopez Del Valle
We document the diffusion of nebulized ibuprofen in Argentina as a treatment for COVID-19. As the pandemic spread, this clinically unsupported drug reached thousands of patients, even some seriously ill, despite warnings by the regulator and medical societies. Detailed...
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Keywords:
COVID-19;
Health Care and Treatment;
Health Pandemics;
Adoption;
Behavior;
Governing Rules, Regulations, and Reforms;
Learning
Calónico, Sebastian, Rafael Di Tella, and Juan Cruz Lopez Del Valle. "The Political Economy of a 'Miracle Cure': The Case of Nebulized Ibuprofen and Its Diffusion in Argentina." NBER Working Paper Series, No. 31781, October 2023.
- October 2023
- Article
Laboratory Safety and Research Productivity
By: Alberto Galasso, Hong Luo and Brooklynn Zhu
Are laboratory safety practices a tax on scientific productivity? We examine this question by exploiting the substantial increase in safety regulations at the University of California following the shocking accidental death of a research assistant in 2008....
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Keywords:
Economics Of Science;
Risk Perception;
Safety Regulations;
Governing Rules, Regulations, and Reforms;
Working Conditions;
Safety;
Performance Productivity
Galasso, Alberto, Hong Luo, and Brooklynn Zhu. "Laboratory Safety and Research Productivity." Art. 104827. Research Policy 52, no. 8 (October 2023).
- September 2023 (Revised October 2023)
- Case
Ghassan Nuqul and the Nuqul Group: Preserving a Father's Legacy
By: Christina R. Wing, Lauren Cohen and Alpana Thapar
The Nuqul Group was established in 1952 by Elia Nuqul, a Palestinian refugee who fled his hometown in 1948 with his family to Jordan. He overcame many hardships in his initial years there, but subsequently started a trading business that grew to become one of Jordan’s...
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Keywords:
Jordan
Wing, Christina R., Lauren Cohen, and Alpana Thapar. "Ghassan Nuqul and the Nuqul Group: Preserving a Father's Legacy." Harvard Business School Case 624-030, September 2023. (Revised October 2023.)
- June 2023
- Case
Verve Therapeutics: Taking DNA Editing to Heart
By: Shikhar Ghosh and Shweta Bagai
Verve Therapeutics, a public biotech company based in Boston, created a novel approach to addressing cardiovascular disease (CVD) - a leading cause of deaths globally. The company's approach was a single shot treatment to permanently lower cholesterol, thus reducing...
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Keywords:
AI;
Genetic Engineering;
Medicine;
Health Care and Treatment;
Genetics;
Innovation Strategy;
Business and Stakeholder Relations;
Medical Specialties;
Innovation and Invention;
Entrepreneurship;
Biotechnology Industry
Ghosh, Shikhar, and Shweta Bagai. "Verve Therapeutics: Taking DNA Editing to Heart." Harvard Business School Case 823-113, June 2023.
- May 25, 2023
- Article
How to Build a Life: Think About Your Death and Live Better
By: Arthur C. Brooks
Brooks, Arthur C. "How to Build a Life: Think About Your Death and Live Better." The Atlantic (May 25, 2023).
- January–February 2023
- Article
Forecasting COVID-19 and Analyzing the Effect of Government Interventions
By: Michael Lingzhi Li, Hamza Tazi Bouardi, Omar Skali Lami, Thomas Trikalinos, Nikolaos Trichakis and Dimitris Bertsimas
We developed DELPHI, a novel epidemiological model for predicting detected cases and deaths in the prevaccination era of the COVID-19 pandemic. The model allows for underdetection of infections and effects of government interventions. We have applied DELPHI across more...
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Keywords:
COVID-19 Pandemic;
Epidemics;
Analytics and Data Science;
Health Pandemics;
AI and Machine Learning;
Forecasting and Prediction
Li, Michael Lingzhi, Hamza Tazi Bouardi, Omar Skali Lami, Thomas Trikalinos, Nikolaos Trichakis, and Dimitris Bertsimas. "Forecasting COVID-19 and Analyzing the Effect of Government Interventions." Operations Research 71, no. 1 (January–February 2023): 184–201.
- 2023
- Working Paper
Life After Death: A Field Experiment with Small Businesses on Information Frictions, Stigma, and Bankruptcy
By: Shai Benjamin Bernstein, Emanuele Colonnelli, Mitchell Hoffman and Benjamin Iverson
In a randomized control trial (RCT) with U.S. small businesses, we document that a large share of firms are not well-informed about bankruptcy. Many assume that bankruptcy necessarily entails the death of a business and do not know about Chapter 11 bankruptcy, where...
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Bernstein, Shai Benjamin, Emanuele Colonnelli, Mitchell Hoffman, and Benjamin Iverson. "Life After Death: A Field Experiment with Small Businesses on Information Frictions, Stigma, and Bankruptcy." NBER Working Paper Series, No. 30933, February 2023.
- September 2022
- Case
BancoSol: Financial Inclusion in the Perfect Storm
By: Michael Chu and Carla Larangeira
In the pandemic, financial inclusion icon BancoSol faces a government-mandated year-long deferral of all loan payments, followed by the sudden Covid death of its CEO. In a Bolivia mired in political turmoil following a failed presidential election, with clients not...
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Keywords:
Decision Making;
Crisis Management;
Management Succession;
Business Strategy;
Innovation Leadership;
Risk and Uncertainty;
Financing and Loans;
Restructuring;
Financial Services Industry;
Latin America;
Bolivia
Chu, Michael, and Carla Larangeira. "BancoSol: Financial Inclusion in the Perfect Storm." Harvard Business School Case 323-023, September 2022.
- July 2022
- Case
General Mills: Responding to the Killing of George Floyd (A)
By: Debora L. Spar and Alicia Dadlani
Jeff Harmening, CEO of General Mills, one of the world's largest manufacturers of breakfast cereals and packaged foods, was deeply disturbed and instantly aware that he and General Mills would need to respond. George Floyd, an African-American man who had been accused...
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Keywords:
Race;
Decisions;
Social Issues;
Corporate Social Responsibility and Impact;
Consumer Products Industry;
Food and Beverage Industry;
Minneapolis;
Minnesota;
United States
Spar, Debora L., and Alicia Dadlani. "General Mills: Responding to the Killing of George Floyd (A)." Harvard Business School Case 323-019, July 2022.
- July 2022
- Supplement
General Mills: Responding to the Killing of George Floyd (B)
By: Debora L. Spar and Alicia Dadlani
Jeff Harmening, CEO of General Mills, one of the world's largest manufacturers of breakfast cereals and packaged foods, was deeply disturbed and instantly aware that he and General Mills would need to respond. George Floyd, an African-American man who had been accused...
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Keywords:
Race;
Decisions;
Social Issues;
Corporate Social Responsibility and Impact;
Consumer Products Industry;
Minneapolis;
Minnesota;
United States
Spar, Debora L., and Alicia Dadlani. "General Mills: Responding to the Killing of George Floyd (B)." Harvard Business School Supplement 323-020, July 2022.
- June 2022
- Teaching Plan
Lifebank Nigeria
By: Brian Trelstad, Pippa Tubman Armerding and Wale Lawal
The aspiration of addressing maternal deaths in Nigeria, which were mostly caused by blood shortages, led Temie Giwa-Tubosun to found LifeBank in 2015. LifeBank developed an online platform that enabled hospitals to connect and purchase blood from local blood banks and...
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- April 12, 2022
- Article
Evaluation of Individual and Ensemble Probabilistic Forecasts of COVID-19 Mortality in the United States
By: Estee Y. Cramer, Evan L. Ray, Velma K. Lopez, Johannes Bracher, Andrea Brennen, Alvaro J. Castro Rivadeneira, Michael Lingzhi Li and et al.
Short-term probabilistic forecasts of the trajectory of the COVID-19 pandemic in the United States have served as a visible and important communication channel between the scientific modeling community and both the general public and decision-makers. Forecasting models...
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Keywords:
COVID-19;
Forecasting and Prediction;
Health Pandemics;
Mathematical Methods;
Partners and Partnerships
Cramer, Estee Y., Evan L. Ray, Velma K. Lopez, Johannes Bracher, Andrea Brennen, Alvaro J. Castro Rivadeneira, Michael Lingzhi Li, and et al. "Evaluation of Individual and Ensemble Probabilistic Forecasts of COVID-19 Mortality in the United States." e2113561119. Proceedings of the National Academy of Sciences 119, no. 15 (April 12, 2022). (See full author list here.)
- 2022
- Working Paper
THEMIS: A Framework for Cost-Benefit Analysis of COVID-19 Non-Pharmaceutical Interventions
By: Dimitris Bertsimas, Michael Lingzhi Li and Saksham Soni
Since December 2019, the world has been ravaged by the COVID-19 pandemic, with over 150 million confirmed cases and 3 million confirmed deaths worldwide. To combat the spread of COVID-19, governments have issued unprecedented non-pharmaceutical interventions (NPIs),...
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Keywords:
COVID-19;
Health Pandemics;
Policy;
Framework;
Cost vs Benefits;
Outcome or Result;
United States;
Germany;
Brazil;
Singapore;
Spain
Bertsimas, Dimitris, Michael Lingzhi Li, and Saksham Soni. "THEMIS: A Framework for Cost-Benefit Analysis of COVID-19 Non-Pharmaceutical Interventions." Working Paper, April 2022.
- March 2022
- Article
Where to Locate COVID-19 Mass Vaccination Facilities?
By: Dimitris Bertsimas, Vassilis Digalakis Jr, Alexander Jacquillat, Michael Lingzhi Li and Alessandro Previero
The outbreak of COVID-19 led to a record-breaking race to develop a vaccine. However, the limited vaccine capacity creates another massive challenge: how to distribute vaccines to mitigate the near-end impact of the pandemic? In the United States in particular, the new...
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Keywords:
Vaccines;
COVID-19;
Health Care and Treatment;
Health Pandemics;
Performance Effectiveness;
Analytics and Data Science;
Mathematical Methods
Bertsimas, Dimitris, Vassilis Digalakis Jr, Alexander Jacquillat, Michael Lingzhi Li, and Alessandro Previero. "Where to Locate COVID-19 Mass Vaccination Facilities?" Naval Research Logistics Quarterly 69, no. 2 (March 2022): 179–200.
- Article
Measuring the Scientific Effectiveness of Contact Tracing: Evidence from a Natural Experiment
By: Thiemo Fetzer and Thomas Graeber
Contact tracing has for decades been a cornerstone of the public health approach to epidemics, including Ebola, severe acute respiratory syndrome, and now COVID-19. It has not yet been possible, however, to causally assess the method’s effectiveness using a randomized...
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Fetzer, Thiemo, and Thomas Graeber. "Measuring the Scientific Effectiveness of Contact Tracing: Evidence from a Natural Experiment." Proceedings of the National Academy of Sciences 118, no. 33 (August 17, 2021): 1–4.
- Summer 2021
- Article
Predictable Country-level Bias in the Reporting of COVID-19 Deaths
We examine whether a country’s management of the COVID-19 pandemic relate to the downward biasing of the number of reported deaths from COVID-19. Using deviations from historical averages of the total number of monthly deaths within a country, we find that the...
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Keywords:
COVID-19;
Deaths;
Reporting;
Incentives;
Government Policy;
Health Pandemics;
Health Care and Treatment;
Country;
Crisis Management;
Outcome or Result;
Reports;
Policy
Kobilov, Botir, Ethan Rouen, and George Serafeim. "Predictable Country-level Bias in the Reporting of COVID-19 Deaths." Journal of Government and Economics 2 (Summer 2021).
- August 2021
- Case
Mylestone: Can Multiple Pivots Preserve the Life of a Death Tech Startup?
By: Shikhar Ghosh and Marilyn Morgan Westner
Dave Balter and Jim Myers co-founded Mylestone, a death tech startup that applied technology to transform how grieving people memorialize the dead. The startup addressed a cultural problem and promised to solve a pressing need in the antiquated, multi-billion dollar...
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Keywords:
Pivot;
Startup;
Business Model;
Cryptocurrency;
Ethical Decision Making;
Emotions;
Growth and Development Strategy;
Ethics;
Market Entry and Exit;
Customer Relationship Management;
Loss;
Change Management;
Relationships
Ghosh, Shikhar, and Marilyn Morgan Westner. "Mylestone: Can Multiple Pivots Preserve the Life of a Death Tech Startup?" Harvard Business School Case 822-018, August 2021.
- February 2021
- Supplement
HNA Group: Global Excellence with Chinese Characteristics (C)
By: William C. Kirby, Billy Chan and John P. McHugh
July 2017 was supposed to be a triumphant month for HNA Group. The latest Fortune Global 500 list showed the company had again skyrocketed in its ranking to no. 170, an improvement of over 200 positions from the year prior. Yet earlier that same July, the mysterious...
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Keywords:
Conglomerate;
Airline Industry;
Coronavirus;
Financial Risk;
Debt;
Bankruptcy;
Global Strategy;
Restructuring;
Health Pandemics;
Financial Markets;
Organizational Change and Adaptation;
Financial Condition;
Globalized Firms and Management;
Business and Government Relations;
Air Transportation Industry;
Financial Services Industry;
China
Kirby, William C., Billy Chan, and John P. McHugh. "HNA Group: Global Excellence with Chinese Characteristics (C)." Harvard Business School Supplement 321-123, February 2021.
- 2021
- Working Paper
Status and Mortality: Is There a Whitehall Effect in the United States?
By: Tom Nicholas
Do white collar workers with lower social status in the occupational hierarchy die younger? The influential Whitehall studies of British civil servants identified a strong inverse relationship between employment rank and mortality, but we do not know if this effect...
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Nicholas, Tom. "Status and Mortality: Is There a Whitehall Effect in the United States?" Harvard Business School Working Paper, No. 21-080, January 2021.
- December 2020
- Supplement
France Télécom (B): A Wave of Staff Suicides
In the B case we learn that at least 19 France Telecom employees took their own lives between 2006 and 2009, 12 others attempted suicide, and eight suffered from serious depression for reasons reportedly related to work. Some of these deaths occurred in public places,...
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Keywords:
Mental Health;
Change;
Crime and Corruption;
Ethics;
Health;
Human Capital;
Human Resources;
Labor and Management Relations;
Labor Unions;
Law;
Social Psychology;
Strategy;
Leadership Style;
Organizations;
Problems and Challenges;
Relationships;
Crisis Management;
Employees;
Well-being;
Telecommunications Industry;
Europe;
European Union
Montgomery, Cynthia A., and Ashley V. Whillans. "France Télécom (B): A Wave of Staff Suicides." Harvard Business School Supplement 721-421, December 2020.